LSD-25

LSD-25  is the most well-known psychedelic, used as a recreational psychoactive drug, as well as a tool in various transcendent practices such as meditation, psychonautics, and psychedelic psychotherapy. 
LSD is characterized by very low dosages and is taken sublingually or orally.

Dosing:

• Microdosing: 25 - 50 mcg
• Weak: 50 - 75 mcg
• Medium: 75 - 200 mcg
• Strong: 200 - 400 mcg
• Very strong: 450+ mcg

The effects of LSD typically last from 6 to 12 hours, depending on the dose, tolerance, body weight, and age. The pharmaceutical company Sandoz warned: "periodic affective disorders can sometimes persist for several days."

Mental changes usually begin 15-20 minutes after taking LSD; they are characterized by mood changes, distortion of environmental perception, and cognitive and behavioral impairments. Euphoria, delusions of reference, and a feeling of transcendence, invulnerability, and detachment often develop; a chaotic mix of euphoria and dysphoria, laughter and painful anxiety, and motor agitation may occur.

When taking large doses of LSD, profound changes in consciousness are possible at the peak of intoxication: delirium, a twilight state, or oneiroid with dream-like experiences of a religious, cosmic, or fantastic nature. Under certain circumstances, LSD can cause or exacerbate pre-existing mental disorders.

The psychedelic effects of LSD-25 can be quickly terminated by an intramuscular injection of 50 mg of chlorpromazine (Data from the annotation for the drug DELISID).

LSD Toxicity and Lethal Dosage

The toxicity of LSD has been studied across multiple animal species. The standard toxicity measurement is the LD-50 index - the median lethal dose at which 50% of test subjects die. For LSD, this value varies significantly between species:

• Mice: 50-60 mg/kg (intravenous administration)
• Rats: 16.5 mg/kg
• Rabbits: 0.3 mg/kg

A documented case involved an elephant that died minutes after receiving 0.297 grams of LSD. With an estimated weight of 5,000 kg, this equates to 0.06 mg/kg. While this single case shouldn't be generalized, it suggests proportional sensitivity - the elephant's lethal dose was approximately 1,000 times lower than that of mice.

Most animal fatalities from LSD result from respiratory arrest.

These small lethal doses might suggest high toxicity. However, when compared to the human effective dose (0.0003-0.001 mg/kg), LSD demonstrates remarkably low toxicity. A lethal human dose would require:

• 300-600 times the effective dose (based on rabbit data)
• 50,000-100,000 times the effective dose (based on mouse data)
  
  These comparative toxicity estimates should be understood as approximate magnitude assessments, as therapeutic index (the ratio between effective and lethal doses) only has meaning within specific species.
  
  Human Safety Profile
  No confirmed human deaths have resulted directly from LSD toxicity. The primary risks involve unpredictable psychological effects rather than physical toxicity.
  
  Chromosomal and Teratogenic Effects
  Early reports in popular media suggested LSD causes chromosomal damage and birth defects. However, comprehensive follow-up studies with statistically significant sample sizes found:

• No correlation between LSD use and chromosomal abnormalities

No evidence linking LSD to fetal deformities in pregnant users

Tolerance to LSD develops relatively quickly, but it decreases rapidly after discontinuing use.

The synthesis of LSD involves a rare precursor of plant origin, ergotamine, which is obtained from ergot, which is itself poisonous. Therefore, pure LSD is a difficult-to-access substance, and many unscrupulous dealers sell LSD analog psychedelics such as DOB, NBOMe, etc., under the guise of LSD. Quality control methods have been developed for LSD:

Ehrlich and Hofmann LSD tests

LSD testing protocol

LSD is sold as solutions for impregnating carriers, as well as in ready-to-use forms like blotters (small pieces of paper), pieces of sugar, jelly, or gelatin.

The LSD molecule is unusually fragile and decomposes when exposed to air, heat, and light. However, when stored in an aqueous solution, in a dark, cool place, without access to light and air, it remains stable indefinitely.

SETTING RULES

1. Make sure that you can spend the near future in calm and comfortable conditions. An LSD trip lasts quite a long time; for 100 mcg - up to 6-7 hours. The effect gradually decreases over the next few hours. Deal with your obligations in advance to be sure that you don't need to rush anywhere and that no one will disturb you. It is better to take LSD no later than 12 hours before bedtime because there may be problems with falling asleep. Buy yourself some light food in advance to eat after the effect has completely worn off.

2. Make sure you calculate the dosage correctly for yourself. If you cannot decide, try 100-120 mcg. Increase the dose to 175-200 mcg or more only if you already have prior experience. If you want to try but are anxious, take 50 mcg; you will feel a slight but noticeable change in mood and perception, but a strong alteration of consciousness will not occur.

3. Place the blotter under your tongue and leave it for 10 minutes, until the paper is almost dissolved, or swallow it immediately, washed down thoroughly with clean water.

4. After that, you have 30-60 minutes before the LSD takes effect. This is another opportunity to prepare anything that might be useful. Many people like to write down their ideas and feelings, so grab a pen or prepare a laptop, although depending on the intensity of the trip, you may not need it. If you are interested in solving specific emotional or psychological problems, make a list of questions you want to think about.

5. The first effects will become noticeable as changes in the perception of the world. You may detect changes in vision: rainbow halos around lights, trails behind moving objects, geometric shapes with your eyes closed, moving, twisting, crawling patterns on the surface of objects. These effects may be interesting, but don't let them distract you from being aware of your essence, your life, and your perception of the world.

6. When LSD starts to work (after 60-90 minutes), you will notice that thoughts and emotions have changed. The effects can vary greatly depending on the person or the occasion. LSD dissolves mental thresholds, allowing you to delve deeper into yourself. You may feel strong happiness or sadness, become pensive or absent-minded, or get very carried away by a particular idea. It's important to remember two things:

   • Stay open to your feelings and let them flow through you easily, with love, and strive to reduce resistance as much as possible.

   • If you are stuck on a bad thought or emotion, start thinking about something good and notice how quickly your condition changes.
     Usually, it is much easier to manage your mood and feelings with LSD, compared to other psychedelics and even compared to an ordinary state of consciousness.

7. Try to stay as open as possible to your feelings and ideas. The longer you can remain open to even the heaviest feelings, the more meaningful and effective the experience will be. If you're thinking about difficulties in your life or things that cause anxiety and depression, try to find ways to accept those feelings and find new solutions to your problems.

8. Don't forget to spend some of your time with LSD just on relaxation. This will allow you not only to relax but also to discover how solutions to important questions, which you didn't even plan to think about, can emerge.

9. When LSD begins to "let you go," you will have a few hours to feel a gradual return to your previous state. This can be a good time to write down your experience or talk to friends or loved ones about it. The return can be a little frustrating as the usual mental and psychological complexes characteristic of your ordinary life will begin to reappear. Take some time to reflect on your experiences and remind yourself to bring some of that openness into your daily life.
   
   LSD can be used for microdosing to improve cognitive functions, emotional state, and general well-being without inducing psychedelic effects.
   
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   Psychedelic bad trip
   
   How to Stop a Psychedelic Trip
   
   How LSD works?
   
   Trip Sitter. Basics and Directions
   
   First Aid for Bad Trip

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